Key result
Diastolic dysfunction linked to high arrhythmic death or resuscitated cardiac arrest risk regardless of LVEF.
Why the study?
Patients with ischemic or dilated cardiomyopathy and reduced LVEF face high ventricular arrhythmia risk, and exact diastolic function grading might improve risk stratification for arrhythmic death.
Does diastolic dysfunction predict arrhythmic death or resuscitated cardiac arrest in patients with cardiomyopathy or normal LVEF?
Cohort (n=210)
Does diastolic dysfunction predict arrhythmic death or resuscitated cardiac arrest in patients with cardiomyopathy or normal LVEF?
Diastolic dysfunction grading may improve risk stratification for arrhythmic death and resuscitated cardiac arrest, independent of LVEF.
Answers are grounded in this paper and cite their sources.
May refine arrhythmic risk stratification via diastolic grading beyond LVEF; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: Patients with ischemic or dilated cardiomyopathy and reduced left ventricular ejection fraction (LVEF) face a high risk for ventricular arrhythmias. Exact grading of diastolic function might improve risk stratification for arrhythmic death. METHODS: We prospectively enrolled 120 patients with ischemic, 60 patients with dilated cardiomyopathy, and 30 patients with normal LVEF. Diastolic function was graded normal (N) or dysfunction grade I to III. Primary outcome parameter was arrhythmic death (AD) or resuscitated cardiac arrest (RCA). CONCLUSIONS: Diastolic dysfunction is associated with a high risk for AD or RCA regardless if LVEF is ≤35% or >35%. Diastolic function grading might improve risk stratification for AD.
No takes yet. Share an insight, caveat, or question.
Pezawas et al. (2020) conducted a cohort in Ischemic or dilated cardiomyopathy (n=210). Diastolic dysfunction vs. Normal diastolic function was evaluated on Arrhythmic death (AD) or resuscitated cardiac arrest (RCA) (p=<0.001). Diastolic dysfunction is associated with a high risk for arrhythmic death or resuscitated cardiac arrest regardless of whether LVEF is ≤35% or >35% (P<0.001).
Synapse has enriched 10 related papers. Consider them for comparative context: