Key result
Diastolic dysfunction in critically ill patients was associated with increased 90-day mortality compared to normal diastolic function (OR 5.1; 95% CI 1.6-16.5; p=0.006).
Why the study?
Left ventricular diastolic dysfunction is important in critically ill patients, but its prevalence and impact on mortality have not been well studied.
Does isolated diastolic dysfunction increase the risk of mortality in critically ill patients with normal left ventricular systolic function?
Observational (n=218)
No
Does isolated diastolic dysfunction increase the risk of mortality in critically ill patients with normal left ventricular systolic function?
Odds Ratio: 5.1 (95% CI 1.6–16.5)
p-value: p=0.006
Isolated diastolic dysfunction is common in critically ill patients with normal systolic function and is independently associated with a significantly increased risk of 90-day mortality.
Isolated DD may flag higher mortality risk in ICU patients with preserved EF; leaves open whether routine grading should inform management.
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Cavefors et al. (2023) conducted an observational in critically ill patients (n=218). Diastolic dysfunction vs. Normal diastolic function was evaluated on death at 90 days (OR 5.1, 95% CI 1.6-16.5, p=0.006). Diastolic dysfunction in critically ill patients was associated with increased 90-day mortality compared to normal diastolic function (OR 5.1; 95% CI 1.6-16.5; p=0.006).
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