September 1, 2010Expert Review of Cardiovascular Therapy
Percutaneous left ventricular assist devices for high-risk percutaneous coronary intervention
Key result
Prophylactic placement of the Impella LP2.5 percutaneous mechanical assist device appears promising for providing adequate circulatory support with a low complication rate during high-risk PCI.
Why the study?
Does prophylactic placement of a percutaneous mechanical assist device prevent profound hypotension and mortality in surgery-ineligible patients with complex coronary artery disease and reduced left ventricular function undergoing high-risk percutaneous coronary intervention?
Population
Surgery-ineligible patients with complex coronary artery disease and reduced left ventricular function…
Design
Review
Authors
Discussion
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Implication
May support prophylactic Impella LP2.5 in high-risk PCI; leaves open confirmation via randomized trials before practice change.
Structured PICO
Does prophylactic placement of a percutaneous mechanical assist device prevent profound hypotension and mortality in surgery-ineligible patients with complex coronary artery disease and reduced left ventricular function undergoing high-risk percutaneous coronary intervention?
P
Population
Surgery-ineligible patients with complex coronary artery disease and reduced left ventricular function undergoing high-risk percutaneous coronary intervention
I
Intervention
Prophylactic placement of a percutaneous mechanical assist device (Impella LP2.5)
Prophylactic use of the Impella LP2.5 device appears to be a promising strategy to provide circulatory support and prevent hypotension during high-risk PCI in surgery-ineligible patients with complex CAD and reduced LVEF.
Limitations
- Randomized evidence is still pending
- randomized evidence is still pending
Cite This Study
Engström et al. (2010) conducted a review in Complex coronary artery disease in surgery-ineligible patients with reduced left ventricular function. Impella LP2.5 device was evaluated. Prophylactic placement of the Impella LP2.5 percutaneous mechanical assist device appears promising for providing adequate circulatory support with a low complication rate during high-risk PCI.