October 24, 1997Science
Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
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Implication
Randomized trial explores gene expression changes during metabolic shifts in yeast, indicating key genetic control mechanisms.
Key Points
- This research aims to investigate how metabolic shifts affect gene expression in yeast at a genomic level.
- Utilized DNA microarrays to analyze the gene expression of Saccharomyces cerevisiae during fermentation to respiration shifts.
- Identified genes affected by TUP1 deletion and YAP1 overexpression.
- Conducted a comprehensive analysis of expression profiles for known and unknown genes.
- Highlighted specific gene expression changes during the diauxic shift accompanying metabolic reprogramming.
- Revealed potential functions for many previously uncharacterized genes based on their expression patterns.
- Demonstrated the effectiveness of DNA microarrays for genomewide exploration of gene expression.
Cite This Study
DeRisi et al. (1997) studied this question.