Key result
A return map memory model reproduced cardiac tissue dynamics unexplained by a unidimensional restitution relation, confirming the restitution curve slope is not predictive of alternans.
Computational modeling demonstrates that cardiac memory is required to accurately predict the onset of action potential alternans, challenging the traditional reliance on restitution curve slope.
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Questions restitution slope for alternans prediction in models; leaves open memory-inclusive validation before clinical use.
Theoretical studies have indicated that alternans (period-doubling instability) of action potential duration is associated with a restitution relation with a slope >or=1. However, recent experimental findings suggest that the slope of the restitution relation is not necessarily predictive of alternans. Here, we compared a return map memory model to action potential data from an ionic model and found that the memory model reproduced dynamics that could not be explained by a unidimensional restitution relation. Using linear stability analysis, we determined the onset of the alternans in the memory model and confirmed that the slope of the restitution curve was not predictive.
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Fox et al. (2002) studied Cardiac tissue alternans. Return map memory model vs. Unidimensional restitution relation was evaluated on Onset of alternans. A return map memory model reproduced cardiac tissue dynamics unexplained by a unidimensional restitution relation, confirming the restitution curve slope is not predictive of alternans.
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