Thrombospondin Type 1 Repeats Interact with Matrix Metalloproteinase 2
Key result
Thrombospondins 1 and 2 interact with matrix metalloproteinase 2 and inhibit MMP activity, suggesting they may inhibit angiogenesis by preventing activation of MMP2 and MMP9 zymogens.
Population
Yeast two-hybrid system, tissue culture, and in vitro assays using purified intact TSP1, TSP2, MMP2, and MMP9
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Hypothesis-generating for thrombospondin-MMP interactions in angiogenesis; leaves open translation to human cardiovascular disease.
Structured PICO
P
Population
Yeast two-hybrid system, tissue culture, and in vitro assays using purified intact TSP1, TSP2, MMP2, and MMP9
I
Intervention
Thrombospondin type 1 repeats (TSR) and intact TSP1
O
Outcome
Protein interaction between TSR and MMPs, and effect on MMP activitysurrogate
Thrombospondins may inhibit angiogenesis by interacting with and preventing the activation of matrix metalloproteinases MMP2 and MMP9.
Cite This Study
Bein et al. (2000) studied Angiogenesis. Thrombospondin 1 and 2 properdin-like type 1 repeats (TSR) was evaluated on Protein interaction and MMP activity. Thrombospondins 1 and 2 interact with matrix metalloproteinase 2 and inhibit MMP activity, suggesting they may inhibit angiogenesis by preventing activation of MMP2 and MMP9 zymogens.