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Randomized trial examines cognitive impairment linked to white matter hyperintensity in cerebral small vessel disease, suggesting new insights into brain function.
BACKGROUND: Cognitive dysfunction in cerebral small vessel disease (CSVD) patients is associated with white matter hyperintensity (WMH), which demonstrates frequency-dependent correlations with brain functional activities. However, the neural mechanisms underlying the relationship between these structural and functional abnormalities and cognitive impairment remain unclear. Simple and multiple mediation analyses were performed to examine the relationships among WMH, functional brain measures, and global cognition. RESULTS: CSVD patients exhibited frequency-specific alterations in regional activity and reduced global functional organization in the slow-4 band. Frequency-dependent functional measures in the slow-4 band significantly mediated the relationship between deep WMH and cognitive performance. CONCLUSION: Our findings demonstrate the frequency-specific mediating role of abnormal brain functions in the pathophysiological pathway linking WMHs to cognitive impairment. This study provides new insight into the pathological mechanisms underlying WMH-related cognitive dysfunction. CLINICAL TRIAL REGISTRATION: ChiCTR2100043346, 02 November 2021, https://www.chictr.org.cn/showproj.html?proj=52285.
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Fan et al. (2025) studied this question.
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