Why the study?
Secondary mitral regurgitation is common in patients with LBBB undergoing CRT, prompting investigation into CRT effects on LV and MV geometry and their correlation with MR severity.
Does cardiac resynchronization therapy improve left ventricular and mitral valve geometry and reduce secondary mitral regurgitation severity in patients with left bundle branch block?
Does cardiac resynchronization therapy improve left ventricular and mitral valve geometry and reduce secondary mitral regurgitation severity in patients with left bundle branch block?
Cardiac resynchronization therapy induces left ventricular and mitral valve geometric reverse remodeling and decreases secondary mitral regurgitation severity in patients with LBBB.
BACKGROUND: Secondary mitral regurgitation (MR) is common in patients with left bundle branch block (LBBB) undergoing cardiac resynchronization therapy (CRT). We aimed to define CRT effects on left ventricular (LV) and mitral valve (MV) geometry, and their correlation with MR severity. METHODS: Forty-one patients with LBBB and ≥mild secondary MR underwent CRT between 2009 and 2012, and had baseline and follow-up echocardiograms available. Repeated measure and linear regression analyses were performed to assess for changes in MV and LV geometry and MR severity, and associations with follow-up MR grade. RESULTS: = 0.4, P = .008), independent of QRS duration (β/ms=-0.07; P = 0.6) and nonischemic cardiomyopathy (β = -0.34, P = .02). CONCLUSIONS: Cardiac resynchronization therapy in patients with LBBB and secondary MR results in LV and MV geometric reverse remodeling and decreases MR severity. Extent of baseline MV tethering is independently associated with persistent MR at follow-up.
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Mihos et al. (2019) studied this question.
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