Key result
CRT linked to a ~44% reduction in exercise-induced MR at 3 months.
Why the study?
Exercise-induced mitral regurgitation carries a poor prognosis in congestive heart failure, but the effects of cardiac resynchronization therapy on exercise-induced mitral regurgitation remained undetermined.
Does cardiac resynchronization therapy improve exercise-induced mitral regurgitation and cardiopulmonary performance in patients with congestive heart failure?
Comparison
Serial evaluation prior to CRT, within 1 week, and 3 months after CRT
Design
Prospective cohort study
Follow-up
3 months
Authors
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Late reduction in exercise MR after CRT supports reverse remodeling mechanism; leaves open acute effects on cardiopulmonary performance.
Observational (n=28)
Does cardiac resynchronization therapy improve exercise-induced mitral regurgitation and cardiopulmonary performance in patients with congestive heart failure?
Absolute Event Rate: 0.19% vs 0.34%
p-value: p=0.001
CRT reduces exercise-induced mitral regurgitation only as a late effect (at 3 months) associated with reverse LV remodeling, rather than as an immediate consequence of resynchronization.
Maďarič et al. (2007) conducted an observational in Congestive heart failure (n=28). Cardiac resynchronization therapy vs. Prior to CRT (baseline) was evaluated on Exercise-induced mitral regurgitation (effective regurgitant orifice in cm2) (p=0.001). Cardiac resynchronization therapy did not immediately attenuate exercise-induced mitral regurgitation, but at 3 months significantly reduced it (ERO 0.19 cm2 vs 0.34 cm2 at baseline, P=0.001).
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