Why the study?
Does cardiac resynchronization therapy improve functional mitral regurgitation and exercise performance in patients with chronic heart failure?
Does cardiac resynchronization therapy improve functional mitral regurgitation and exercise performance in patients with chronic heart failure?
This review summarizes the pathophysiological mechanisms by which CRT reduces functional mitral regurgitation and improves exercise capacity in patients with chronic heart failure.
May support CRT consideration for functional MR in HF; leaves open randomized confirmation of exercise and QoL benefits.
Cardiac resynchronization therapy (CRT) has emerged as an established therapy for patients with end-stage heart failure (HF) and symptoms refractory to optimal medication. Resynchronization of the ventricles leads to reduced functional mitral regurgitation (MR) both acutely and chronically and to a better haemodynamic and energetic profile. In addition, large clinical trials have confirmed its beneficial effect on exercise performance and quality of life. The link between the pathophysiological mechanisms of CRT and its positive effect on clinical status has not been fully elucidated. Therefore, this review will focus on the effect of CRT on the haemodynamic role of functional MR and its impact on exercise performance in patients with chronic HF.
No takes yet. Share an insight, caveat, or question.
Parthenakis et al. (2008) studied this question.