Key result
Renal denervation via cryoablation inhibits AF inducibility and shortens AF duration.
Why the study?
Catheter-based RDN can reduce cardiac sympathetic nerve activity and inhibit AF, but its reliability is uncertain because renal sympathetic nerves are mainly distributed in the renal artery adventitia.
Does renal denervation via renal artery adventitial cryoablation reduce atrial fibrillation vulnerability and duration?
Does renal denervation via renal artery adventitial cryoablation reduce atrial fibrillation vulnerability and duration?
Answers are grounded in this paper and cite their sources.
Renal artery adventitial cryoablation may effectively inhibit atrial fibrillation inducibility and duration through cardiac neural remodeling in a preclinical model.
INTRODUCTION: Catheter-based renal denervation (RDN) could reduce cardiac sympathetic nerve activity (SNA) and inhibit atrial fibrillation (AF). However, the reliability is uncertain, because the renal sympathetic nerves are mainly distributed in the adventitial surface of the renal artery. OBJECTIVE: The aims of this study were to test the hypothesis that renal artery adventitial ablation (RAAA) definitely had the effects of RDN and to study the effects of RDN via renal artery adventitial cryoablation (RAAC) on AF and cardiac neural remodeling. METHODS: =10). After 2 months of postoperative recovery, AF vulnerability, AF duration, and histological examination were performed in both groups. CONCLUSIONS: RDN via RAAC could cause cardiac neural remodeling and effectively inhibit AF inducibility and shorten AF duration. It may be useful in selecting therapeutic approaches for AF patients.
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Wang et al. (2018) studied Atrial Fibrillation. Renal denervation via renal artery adventitial cryoablation (RAAC) was evaluated on AF vulnerability and AF duration (p=0.024). Renal denervation via renal artery adventitial cryoablation effectively inhibited atrial fibrillation inducibility and shortened atrial fibrillation duration (p=0.024).
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