Key result
Catheter-based renal denervation cuts left atrial AF complexity ~44% and nerve sprouting in goats.
Why the study?
Does percutaneous catheter-based renal denervation reduce atrial nerve sprouting and AF complexity in a goat model of persistent AF?
Population
18 goats instrumented with an atrial endocardial pacemaker lead and a burst pacemaker, with AF induced and…
Comparison
Percutaneous catheter-based renal denervation vs Sham procedure
Design
Preclinical
Follow-up
6 weeks
Authors
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Should not change AF practice; extends animal data on renal denervation and leaves open human trials.
Does percutaneous catheter-based renal denervation reduce atrial nerve sprouting and AF complexity in a goat model of persistent AF?
Absolute Event Rate: 4.8% vs 8.5%
p-value: p=0.001
In a goat model of persistent AF, renal denervation reduced atrial sympathetic nerve sprouting, structural alterations, and AF complexity independent of blood pressure changes.
Linz et al. (2015) studied Atrial fibrillation (n=18). Percutaneous catheter-based renal denervation vs. Sham procedure was evaluated on Left atrial AF complexity (fibrillation waves/AF cycle length) (p=0.001). Catheter-based renal denervation reduced left atrial AF complexity (4.8 vs 8.5 fibrillation waves/AF cycle length, P=0.001) and atrial nerve sprouting in goats with persistent AF.
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