Key result
Right ventricular dysfunction in HFpEF is linked to worse LV function, symptoms, and overall survival.
Why the study?
Although historically ignored, the right ventricle modulates left ventricular structure and function and plays a key prognostic role in left heart failure, prompting a review of right heart failure as a cause of left heart failure.
Does right ventricular dysfunction affect the prognosis and symptoms of left heart failure?
Systematic Review (n=1,134)
Does right ventricular dysfunction affect the prognosis and symptoms of left heart failure?
Right ventricular dysfunction is a key prognostic factor in left heart failure and should be considered a therapeutic target, particularly in HFpEF.
Background: Heart failure is a clinical syndrome characterized by symptoms such as dyspnea and fluid retention in the context of structural abnormalities of the heart. For many years, the importance of the right heart was ignored or forgotten, however, it has been revealed that the right ventricle is a key part in the prognosis of left heart failure. The right ventricle modulates the structure and function of the left ventricle. Interest arises in carrying out a bibliographic review on right heart failure as a cause of left heart failure. Material and methods: The study design was a systematic review of the literature available in PubMED, this review was of a quantitative-qualitative nature, through exhaustive and specific searches using MESH terminologies and boulean operators. Results: A total of 7 scientific articles were analyzed, with a total of 1134 patients, with a mean of 226. The most prevalent associated comorbidities were: arterial hypertension, diabetes, obesity and coronary disease. Conclusion: It is concluded that as a new therapeutic objective of HFpEF, something in which most of the authors of the analyzed articles agree, the focus should be placed on the treatment of right ventricular dysfunction.Right ventricular dysfunction is common and affects the normal function of the left ventricle, also impacting the symptoms and the chance of survival
No takes yet. Share an insight, caveat, or question.
GOMES et al. (2023) conducted a systematic review in Heart failure with preserved ejection fraction (HFpEF) and right ventricular dysfunction (n=1,134). Right ventricular dysfunction (exposure) was evaluated. Right ventricular dysfunction is common in heart failure with preserved ejection fraction and negatively affects left ventricular function, symptoms, and overall survival.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: