Why the study?
Cardiac thrombi are a major risk factor for ischemic stroke but are rarely diagnosed in the acute phase.
Does the presence of a cardiac thrombus detected by acute-phase cardiac CT worsen functional outcome or increase stroke recurrence in patients with acute ischemic stroke?
Population
Consecutive adult patients with acute ischemic stroke undergoing acute prospective ECG-gated cardiac CT
Comparison
Patients with a cardiac thrombus on CT vs those without
Design
Prospective cohort substudy
Follow-up
90 days
Key result
The presence of a cardiac thrombus detected on CT in patients with acute ischemic stroke was associated with a significantly worse functional outcome at 90 days (aOR 3.18).
Authors
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Cardiac thrombus on acute CT identifies higher-risk ischemic stroke patients; leaves open whether detection should alter antithrombotic management.
Cohort (n=452)
No
Does the presence of a cardiac thrombus detected by acute-phase cardiac CT worsen functional outcome or increase stroke recurrence in patients with acute ischemic stroke?
Effect estimate: aOR 3.18 (95% CI 1.68-6.00)
In patients with acute ischemic stroke, the presence of a cardiac thrombus detected by acute-phase cardiac CT is associated with more severe deficits and worse functional outcomes at 90 days.
Rinkel et al. (2022) conducted a cohort in Acute ischemic stroke (n=452). Presence of cardiac thrombus on CT vs. Absence of cardiac thrombus on CT was evaluated on Worse functional outcome (shift on modified Rankin Scale at 90 days) (aOR 3.18, 95% CI 1.68-6.00). The presence of a cardiac thrombus detected on CT in patients with acute ischemic stroke was associated with a significantly worse functional outcome at 90 days (aOR 3.18).