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Reaction of the ethyl 3-arylpyruvate 5 a with the methyl 2-bromo-3-arylpyruvate 6 b in the presence of the 2-arylethylamine 4 afforded the pyrrole derivative 10, which could be transformed into lamellarin L (1) in five steps. The synthesis proceeds with 38 % overall yield and mimics the probable biosynthesis of these marine alkaloids.
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Peschko et al. (2000) studied this question.
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