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An engineered ACE2 'microbody' fused to a single immunoglobulin Fc domain potently inhibits SARS-CoV-2 entry and replication in vitro and in vivo, exhibiting 10-fold higher potency than standard soluble ACE2. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 2020Cell ReportsOpen Access

An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2

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TTTakuya TadaNew York University FCFan ChenHangzhou Academy of Agricultural Sciences JCJennifer ChenBrown University

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Tada et al. (2020) studied this question.

synapsesocial.com/papers/6a086d3a1e8b9db648de088b https://doi.org/10.1016/j.celrep.2020.108528

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December 1, 2020Cell ReportsOpen Access

An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2

View Full Paper

Ask AI

Bookmark

Authors

TTTakuya TadaNew York University FCFan ChenHangzhou Academy of Agricultural Sciences JCJennifer ChenBrown University

Discussion

Member takes

Implication

Key Points

Key points are not available for this paper at this time.

Cite This Study

Tada et al. (2020) studied this question.

synapsesocial.com/papers/6a086d3a1e8b9db648de088b https://doi.org/10.1016/j.celrep.2020.108528

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