Quantitative mRNA expression profiling in 72 human tissues revealed that ACE 2 is highly expressed in renal, cardiovascular, and gastrointestinal tissues.
Observational (n=72)
ACE 2 is highly expressed in the gastrointestinal system in addition to renal and cardiovascular tissues, suggesting a potential role in GI physiology and pathophysiology.
ACE 2, a novel homologue of angiotensin converting enzyme, has recently been identified. This study used QRT-PCR to quantitatively map the transcriptional expression profile of ACE 2 (and the two isoforms of ACE) in 72 human tissues. While confirming that ACE 2 expression is high in renal and cardiovascular tissues, the novel observation has been made that ACE 2 shows comparably high levels of expression in the gastrointestinal system, in particular in ileum, duodenum, jejunum, caecum and colon. Therefore, in probing the functional significance of this novel peptidase, some consideration should be given to a role in gastrointestinal physiology and pathophysiology.
Harmer et al. (Thu,) reported a observational. Quantitative mRNA expression profiling was evaluated on Transcriptional expression profile of ACE 2. Quantitative mRNA expression profiling in 72 human tissues revealed that ACE 2 is highly expressed in renal, cardiovascular, and gastrointestinal tissues.