Key result
Occupational sitting ≥6.5 hours/day shows no link to increased VTE risk versus ≤3.5 hours/day.
Why the study?
Prolonged seated immobility during long-distance flights increases venous thromboembolism risk, but little is known about the risk related to sedentary work.
Does sedentary work (occupational sitting ≥6.5 hours/day) increase the risk of venous thromboembolism in the general population?
Population
78 936 participants aged <65 years without prior thromboembolic events
Comparison
Occupational sitting ≥6.5 hours/day vs occupational sitting ≤3.5 hours/day
Design
Prospective cohort study
Follow-up
Mean follow-up, 7.4 years
Authors
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Does not support limiting occupational sitting to prevent VTE; leaves open contributions from total sedentary time or other populations.
Cohort (n=78,936)
Yes
Does sedentary work (occupational sitting ≥6.5 hours/day) increase the risk of venous thromboembolism in the general population?
Effect estimate: HR 1.11 (95% CI 0.92-1.34)
This large prospective cohort study found no significant association between sedentary work (≥6.5 hours/day of occupational sitting) and the risk of venous thromboembolism in the general population.
Johannesen et al. (2019) conducted a cohort in Venous thromboembolism (n=78,936). Occupational sitting ≥6.5 hours/day vs. Occupational sitting ≤3.5 hours/day was evaluated on First venous thromboembolism (VTE) event (HR 1.11, 95% CI 0.92-1.34). Occupational sitting ≥6.5 hours/day was not associated with an increased risk of venous thromboembolism compared to ≤3.5 hours/day (HR 1.11; 95% CI 0.92-1.34).
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