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February 10, 2012American Journal of Respiratory and Critical Care MedicineOpen Access

Spurious Inferences about Long-Term Outcomes: The Case of Severe Sepsis and Geriatric Conditions

Theodore J. Iwashyna Giora Netzer Kenneth M. Langa Christine T. Cigolle

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Key Points

This study aims to determine if severe sepsis leads to increased risks of certain geriatric conditions among survivors.
Identified patients with severe sepsis in a nationally representative cohort from 1998 to 2006.
Compared geriatric condition rates in survivors to three different comparators: U.S. population ages 65+, survivors' pre-sepsis levels, and pre-sepsis trajectories.
Followed 623 severe sepsis hospitalizations for a median of 0.92 years.
Severe sepsis was associated with increased rates of low BMI, injurious falls, incontinence, and vision loss compared to the 65+ population.
Survivors' own pre-sepsis levels also showed similar associations for low BMI, falls, and incontinence.
No association was found for severe sepsis with other geriatric conditions after controlling for pre-sepsis trajectories.

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Implication

Assesses long-term outcomes of severe sepsis on geriatric conditions, highlighting important associations.

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Cite This Study

Iwashyna et al. (2012) studied this question.

synapsesocial.com/papers/6a086e74107d9dc007107ada https://doi.org/10.1164/rccm.201109-1660oc

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