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In this article, we report an important extended work of the Hantzsch synthesis of thiazoles by reacting novel 2-amino-N-(aryl/alkyl)-2-thioxoacetamides with bromoacetaldehyde diethyl acetal in DMF at 80 °C. We synthesized required 2-amino-N-(aryl/alkyl)-2-thioxoacetamides by reacting 2-oxo-2-(aryl/alkylamino)ethanedithioates with ammonia, which is generated in situ by mixing ammonium chloride and sodium acetate in acetonitrile at room temperature. We have also proposed a possible mechanism of formation of thiazoles. High yields, comparatively less reaction times and mild conditions are the important features of this procedure.
Honnabandar et al. (Fri,) studied this question.