Key result
Adding stratum-specific likelihood ratios to ROC curve analysis across 4 datasets provided additional diagnostic information, such as reducing strep throat predictor strata from 5 to 3.
Population
Four previously reported datasets including serum creatine kinase for diagnosing acute myocardial infarction…
Design
Other
Authors
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May aid test interpretation in practice; extends ROC methods to quantify spectrum bias in diagnostic studies.
Integrating stratum-specific likelihood ratios with ROC curve analysis provides valuable additional diagnostic information, such as identifying optimal cutpoints and quantitating spectrum bias.
Peirce et al. (1993) studied Various (AMI, strep throat, CT images). Stratum-specific likelihood ratios (SSLRs) was evaluated on Utility of adding SSLRs to ROC curve analysis. Adding stratum-specific likelihood ratios to ROC curve analysis across 4 datasets provided additional diagnostic information, such as reducing strep throat predictor strata from 5 to 3.
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