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October 7, 2018EP Europace

Comparison of electrocardiogram characteristics and pacing parameters between left bundle branch pacing and right ventricular pacing in patients receiving pacemaker therapy

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Why the study?

Does left bundle branch pacing improve electrocardiogram characteristics and pacing parameters compared to conventional right ventricular pacing in pacing-indicated patients?

Population

40 pacing-indicated patients prospectively enrolled

Comparison

Left bundle branch pacing achieved by… vs Conventional right ventricular pacing (RVP)

Design

Cohort

Follow-up

3-month

Key result

Left bundle branch pacing produced a significantly narrower paced QRS duration compared to right ventricular pacing (111.85 ms vs 160.15 ms; P<0.001) with low and stable pacing thresholds.

Authors

KCKeping ChenYLYuqiu LiYDYan Dai

Discussion

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Overview

May support LBBP feasibility for narrower QRS in pacing patients; leaves open outcome benefits versus RVP in randomized trials.

Study Design

Type

Cohort (n=40)

Structured PICO

Does left bundle branch pacing improve electrocardiogram characteristics and pacing parameters compared to conventional right ventricular pacing in pacing-indicated patients?

P
Population
40 pacing-indicated patients prospectively enrolled
I
Intervention
Left bundle branch pacing (LBBP) achieved by transseptal method in the basal ventricular septum
C
Comparator
Conventional right ventricular pacing (RVP)
O
Outcome
Electrocardiogram characteristics, pacing parameters, pacing sites, and safety events assessed at implantation and 3-month follow-upsurrogate

Main Result

Absolute Event Rate: 111.85% vs 160.15%

p-value: p=<0.001

Left bundle branch pacing is clinically feasible, maintains low pacing thresholds, and produces a narrower QRS duration compared to conventional right ventricular pacing.

Cite This Study

Chen et al. (2018) conducted a cohort in Pacing-indicated patients (n=40). Left bundle branch pacing (LBBP) vs. Right ventricular pacing (RVP) was evaluated on Paced QRS duration (p=<0.001). Left bundle branch pacing produced a significantly narrower paced QRS duration compared to right ventricular pacing (111.85 ms vs 160.15 ms; P<0.001) with low and stable pacing thresholds.

synapsesocial.com/papers/6a0871fddf3db87398109598https://doi.org/10.1093/europace/euy252
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