Arthralgia resolution rate following chikungunya virus infection

Figures

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  Figure 1. (A) Map of the study locations. Colored points indicate the location of each study, where the point size represents the relative study sample size. (B) Reported prevalence of arthralgia for each study by month post chikungunya virus infection.

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  Figure 2. Estimated prevalence of arthralgia by months post-chikungunya virus infection. Gray points and lines indicate the reported mean prevalence of arthralgia and the 95% binomial confidence intervals. The purple line and ribbon show the mean and 95% confidence interval for expected arthralgia prevalence estimated across all studies.

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  Figure 3. Estimated rates of resolution by study. (A) Estimated prevalence of arthralgia by months post infection by study. The green lines and ribbons indicate the model mean and 95% confidence interval estimates. The gray points and lines indicate the reported prevalence of arthralgia and 95% binomial confidence intervals. (B) Estimated rate of resolution per month by study. The points and lines indicate mean and 95% confidence intervals. The horizontal dashed line and ribbon indicate the mean and 95% confidence interval estimates from summary model 1. (C) Estimated median time to resolution by study. The points and lines indicate the mean and 95% confidence intervals. The horizontal dashed line and ribbon indicate the mean and 95% confidence interval estimates from summary model 1.

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  Figure 4. Prevalence of arthralgia by months post-chikungunya virus infection estimated by median cohort age (A), circulating viral genotype (B), study follow-up method (C), and region (D). The colored points and lines indicate the reported mean prevalence of arthralgia and 95% binomial confidence intervals. The colored lines and ribbon show the mean and 95% confidence interval for expected arthralgia prevalence estimated across studies by group.