Why the study?
Are elevated baseline inflammatory markers associated with an increased risk of future coronary heart disease in middle-aged men?
Population
1,531 men selected from a cohort of 5,661 men aged 40-59 years.
Comparison
Top third of baseline measurements of… vs Bottom third of baseline measurements of…
Design
Case-control
Follow-up
From 1978-1980 until 1996
Authors
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Elevated CRP may mark higher CHD risk in men; hypothesis-generating for causality and anti-inflammatory prevention trials.
Are elevated baseline inflammatory markers associated with an increased risk of future coronary heart disease in middle-aged men?
Elevated baseline levels of inflammatory markers, particularly C-reactive protein, are independently associated with an increased future risk of coronary heart disease.
John Danesh (2000) studied this question.
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