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September 16, 1997Circulation

Attenuation of Unfavorable Remodeling by Exercise Training in Postinfarction Patients With Left Ventricular Dysfunction

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Why the study?

Does a 6-month exercise training program improve left ventricular size and function in postinfarction patients with systolic dysfunction?

Population

77 consecutive patients with <40% ejection fraction after a first Q-wave myocardial infarction

Comparison

6-month exercise training program vs Control group

Design

RCT, randomly assigned

Follow-up

6 months

Authors

PGPantaleo GiannuzziPTPier Luigi TemporelliUCUgo Corrà

Discussion

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Overview

Supports exercise training in post-MI systolic dysfunction to limit remodeling; confirms RCT benefit for cardiac rehabilitation.

Structured PICO

Does a 6-month exercise training program improve left ventricular size and function in postinfarction patients with systolic dysfunction?

P
Population
77 consecutive patients with <40% ejection fraction after a first Q-wave myocardial infarction
I
Intervention
6-month exercise training program
C
Comparator
Control group
O
Outcome
Left ventricular size (end-diastolic and end-systolic volumes), ejection fraction, and work capacity at 6 monthssurrogate

Long-term exercise training in post-myocardial infarction patients with systolic dysfunction attenuates adverse left ventricular remodeling and improves ejection fraction.

Cite This Study

Giannuzzi et al. (1997) studied this question.

synapsesocial.com/papers/6a0872fa280cd4e998e8bfd7https://doi.org/10.1161/01.cir.96.6.1790
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Progressive left ventricular dysfunction and remodeling after myocardial infarction. Potential mechanisms and early predictors.1993 · 700 citations
  2. 2Exercise training in patients with chronic heart failure delays ventilatory anaerobic threshold and improves submaximal exercise performance.1989 · 298 citations
  3. 3Controlled trial of physical training in chronic heart failure. Exercise performance, hemodynamics, ventilation, and autonomic function.1992 · 954 citations
  4. 4Spontaneous delayed recovery of perfusion and contraction after the first 5 weeks after anterior infarction. Evidence for the presence of hibernating myocardium in the infarcted area.1994 · 132 citations
  5. 5Exercise training in patients with severe left ventricular dysfunction. Hemodynamic and metabolic effects.1988 · 698 citations