Why the study?
Heart and kidney diseases frequently coexist and lead to frequent hospitalizations and premature deaths, highlighting the need to optimize access to care, particularly in low-resource settings.
The KDIGO 2012 clinical practice guideline establishes the standard framework for evaluating and managing chronic kidney disease, introducing the Cause, GFR, and Albuminuria (CGA) classification system.
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Integrates cardio-renal care recommendations into LMIC practice; extends KDIGO framework with targeted access strategies.
The clinical impact of diabetes medications, including sodium-glucose cotransporter-2 inhibitors, non-steroidal mineralocorticoid receptor antagonists, and glucagon-like peptide 1 receptor agonists on cardiovascular and kidney disease outcomes has focused attention on the interrelatedness of kidney and heart health, both within and outside the context of diabetes. These conditions often co-exist, causing frequent hospitalizations and premature deaths. Herein, we provide an updated, comprehensive state-of-the-art review, summarizing the linkages between heart disease and kidney disease, the mechanisms connecting these conditions, common risk factors, management, implications for health systems, and the impact on patients, particularly in low-resource settings. As experts representing the World Heart Federation and the International Society of Nephrology, we highlight areas of opportunity and provide recommendations on improving access to care for the growing numbers of patients with heart and kidney diseases, with a focus on low- and middle-income countries.
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Narula et al. (2025) conducted a review in Heart and kidney diseases. This state-of-the-art review summarizes the linkages between heart and kidney diseases and provides recommendations to improve access to care, particularly in low- and middle-income countries.
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