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May 1, 1984Proceedings of the National Academy of SciencesOpen Access

Organization of collagen types I and V in the embryonic chicken cornea: monoclonal antibody studies.

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Authors

JFJ M FitchTufts UniversityJGJ GrossUniversity of CologneRMRichard MayneUniversity of Oxford

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Implication

Monoclonal antibody studies reveal collagen type V is masked by type I in embryonic chicken corneas, implying structural interactions.

Key Points

  • This research aims to understand how type V collagen is hidden in the embryonic chicken cornea due to its structural arrangement.
  • Probed embryonic chicken cornea sections with monoclonal antibodies against types I and V.
  • Used a lathyritic agent to block collagen crosslinking and observe temperature effects on fibril structure.
  • Applied corneal collagenase treatment to selectively degrade type I collagen for further assessment.
  • Type V collagen was unmasked at 0°C, indicating its binding is affected by fibrillar organization.
  • Collagen type I is identified as the masking agent for type V collagen in the corneal structure.
  • Evidence supports the incorporation of types I and V in heterotypic fibrils.

Cite This Study

Fitch et al. (1984) studied this question.

synapsesocial.com/papers/6a0874daab15ea61dee8dc59https://doi.org/10.1073/pnas.81.9.2791
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Monoclonal antibodies against chicken type V collagen: production, specificity, and use for immunocytochemical localization in embryonic cornea and other organs1983 · 159 citations
  2. 2Covalent Crosslinking between Molecules of Type I and Type III Collagen1982 · 189 citations
  3. 3Comparison of collagen types in adult and fetal bovine corneas.1982 · 56 citations
  4. 4Production and characterization of a monoclonal antibody to chicken type I collagen.1979 · 58 citations
  5. 5MORPHOLOGIC EVIDENCE FOR COLLAGEN CHANGES IN CHICH EMBRYOS TREATED WITH ß-AMINOPROPIONITRILE1959 · 62 citations