Why the study?
Anticoagulant therapy for stroke prevention in AF may have side effects or be contraindicated, prompting surgical and percutaneous left atrial appendage occlusion as non-pharmacological alternatives.
Does surgical and percutaneous left atrial appendage occlusion (LAAO) prevent stroke in patients with atrial fibrillation?
Does surgical and percutaneous left atrial appendage occlusion (LAAO) prevent stroke in patients with atrial fibrillation?
Surgical and percutaneous LAAO are important non-pharmacological alternatives for stroke prevention in AF patients, especially those with contraindications to anticoagulation.
Atrial fibrillation (AF) is the most common arrhythmia worldwide. It is associated with increased mortality and morbidity, especially due to the increased risk of ischemic stroke and systemic embolism in these patients. For this reason, thromboembolism prevention is the cornerstone of managing AF, and oral anticoagulation is nowadays the first-line treatment. However, since most thrombi form in the left atrial appendage and anticoagulant therapy may have side effects and be contraindicated in some patients, surgical and percutaneous left atrial appendage occlusion (LAAO) have emerged as a non-pharmacological alternative. This review summarizes all existing evidence on surgical and percutaneous LAAO.
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Anduaga et al. (2023) studied this question.
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