Abstract “Soft ionization” techniques which permit direct desorptton of gasphase analyte ions without the need for vaporization have greatly expanded the potential applications of mass spectrometry (MS). By using such techniques as field desorption (FD), desorption chemical ionization (DCI), and fast atom bombardment (FAB), thermally labile and higher molecular weight compounds are now amenable to MS exambation without significant thermal degradation. This ability to ionize higher molecular weight species has been paralleled by high field, inhomogeneous magnet development, allowing magnetic sector mass spectrometers to reach 10,000ν at full accelerating voltage. These advancements in ionization techniques and instrument design now permit useful MS data for organic compounds of several thousand molecular weight to be produced on a near routine basis in many laboratories.
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R. L. Cochran (1986) studied this question.
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