Key result
Glycogen phosphorylase BB provides modest diagnostic accuracy for MI, raising probability to 81% when positive.
Why the study?
The study was conducted to investigate the diagnostic accuracy of glycogen phosphorylase BB as a cardiac marker for myocardial infarction.
Does glycogen phosphorylase BB accurately diagnose myocardial infarction?
Meta-Analysis
Does glycogen phosphorylase BB accurately diagnose myocardial infarction?
Glycogen phosphorylase BB has modest diagnostic accuracy for screening myocardial infarction, significantly altering pretest probabilities.
Answers are grounded in this paper and cite their sources.
Modest accuracy advises against standalone MI use; leaves open adjunctive biomarker role pending prospective trials.
PURPOSE: We tried to investigate the diagnostic accuracy of glycogen phosphorylase BB as a cardiac marker for myocardial infarction. METHODS: We searched through different electronic databases (PubMed, Google-scholar, Embase, and Cochrane Library) to locate relevant articles. Studies, with sufficient data to reconstruct a 2 × 2 contingency table, met our inclusion criteria were included. Three reviewers independently screened the articles. Discrepancies were resolved by other reviewers. Unpublished data were requested from the authors of the study via email. Subsequently, data extraction was done using a standardized form and quality assessment of studies using the QUADAS-2 tool. Meta-analysis was done using a bivariate model using R software. RESULTS: = 89%), and AUC of SROC was 0.923. The lambda value of the HSROC curve was 3.670. The Fagan plot showed that GPBB increases the pretest probability of myocardial infarction from 46% to 81% when positive, and it lowers the same probability to 12% when negative. CONCLUSION: With these results, we can conclude that GPBB has modest accuracy in screening myocardial infarction, but the limitations of the study warrant further high-quality studies to confirm its usefulness in predicting myocardial infarction (MI).
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Ghimire et al. (2022) conducted a meta-analysis in myocardial infarction. Glycogen phosphorylase BB was evaluated on Diagnostic accuracy for myocardial infarction (AUC 0.923). Glycogen phosphorylase BB demonstrated modest diagnostic accuracy for myocardial infarction, with an AUC of 0.923, increasing pretest probability from 46% to 81% when positive.
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