Key result
Review summarizes recent clinical updates in HCM including emerging myosin inhibitors and gene therapy.
Why the study?
Recent clinical trials of myosin inhibitors and studies of gene therapy prompted a summary of recent clinical updates across HCM management to provide new ideas for follow-up research.
This review provides a comprehensive update on the epidemiology, diagnosis, and emerging treatments for hypertrophic cardiomyopathy, highlighting the potential of myosin inhibitors and gene therapy.
Myosin inhibitors and gene therapy for hypertrophic cardiomyopathy warrant caution in practice; review leaves open their adoption pending trials.
Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiomyopathy transmitted in an autosomal dominant manner to offspring. It is characterized by unexplained asymmetrical hypertrophy primarily affecting the left ventricle and interventricular septum while potentially causing obstruction within the left ventricular outflow tract (LVOT). The clinical manifestations of HCM are diverse, ranging from asymptomatic to severe heart failure (HF) and sudden cardiac death. Most patients present with obvious symptoms of left ventricular outflow tract obstruction (LVOTO). The diagnosis of HCM mainly depends on echocardiography and other imaging examinations. In recent years, myosin inhibitors have undergone clinical trials and gene therapy, which is expected to become a new treatment for HCM, has been studied. This article summarizes recent clinical updates on the epidemiology, pathogenesis, diagnostic methods, treatment principles, and complication prevention and treatment of HCM, to provide new ideas for follow-up research.
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Zhao et al. (2025) conducted a review in Hypertrophic cardiomyopathy (HCM). This review summarizes recent clinical updates on the epidemiology, pathogenesis, diagnosis, and emerging treatments for hypertrophic cardiomyopathy, including myosin inhibitors and gene therapy.
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