What is the clinical evidence from this study?

Study design: Cohort. Population: Hypertrophic cardiomyopathy (n=137). Intervention: Longitudinal observation. Primary outcome: HCM-related death (sudden death, heart failure death, stroke death).

January 1, 2006Circulation JournalOpen Access

Left Ventricular Remodeling of Hypertrophic Cardiomyopathy Longitudinal Observation in a Rural Community

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Key result

In a rural Japanese cohort of patients with hypertrophic cardiomyopathy, 28 of 137 patients died of HCM-related causes over 11.4 years, with heart failure death becoming predominant after 10 years.

Population

137 consecutive patients with hypertrophic cardiomyopathy in a rural Japanese community. Mean age 52±13…

Design

Cohort

Follow-up

11.4±5.7 years

Authors

HKHiroaki KitaokaHeart Failure & Transplant TKToru KuboHeart Failure & Transplant MOMakoto OkawaKōchi University

Discussion

Member takes

Implication

Long-term HCM follow-up may warrant heart failure vigilance after 10 years; leaves open prospective validation of remodeling-targeted strategies.

Study Design

Type

Cohort (n=137)

Multicenter

Structured PICO

Population

137 consecutive patients with hypertrophic cardiomyopathy (HCM) in a rural Japanese community (Kochi prefecture). Mean age 52±13 years, 68% male. Key inclusion: echocardiographic demonstration of hypertrophied left ventricle (wall thickness ≥15mm) without hypertension and other cardiac diseases.

Outcome

Cardiovascular death (composite of sudden death, heart failure death, and stroke death) and left ventricular remodeling over long-term follow-uphard clinical

In a rural Japanese cohort with hypertrophic cardiomyopathy, heart failure death due to left ventricular remodeling becomes as prominent as sudden death after 10 years of follow-up.

Limitations

The cohort size was relatively small and the design was retrospective
The patient cohort differs from other reports, being older and having less prevalence of LV outflow gradient
No significant difference in previously reported prognostic risk factors of sudden death between survivors and those who died suddenly
Patient management (lack of surgical treatment or ICD for primary prevention) could have affected the results
Small cohort size
Retrospective design
Older patient cohort with less prevalence of LV outflow gradient
No significant difference in previously reported prognostic risk factors of sudden death
Patient management (lack of ICDs/surgical treatment) could have affected results

Cite This Study

Kitaoka et al. (2006) conducted a cohort in Hypertrophic cardiomyopathy (n=137). Longitudinal observation was evaluated on HCM-related death (sudden death, heart failure death, stroke death). In a rural Japanese cohort of patients with hypertrophic cardiomyopathy, 28 of 137 patients died of HCM-related causes over 11.4 years, with heart failure death becoming predominant after 10 years.

synapsesocial.com/papers/6a08823d280cd4e998e8c4dc https://doi.org/10.1253/circj.70.1543

Topics

Echocardiography Hypertrophic cardiomyopathy

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Implication

Long-term HCM follow-up may warrant heart failure vigilance after 10 years; leaves open prospective validation of remodeling-targeted strategies.