The M Cell:
Population
Ventricular myocardium M cells (review including dog models)
Design
Review
Authors
Discussion
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Implication
Highlights need for refined in vivo methods to assess M cells; leaves open their clinical role in arrhythmias.
Key Points
- This review aims to comprehensively characterize the M cell and its effects on electrical heart function and arrhythmias.
- Evaluation of the M cell's action potential and its implications for cardiac electrophysiology.
- Discussion of controversies about transmural heterogeneity of repolarization and recording techniques.
- Analysis of the impact of anesthetics on transmural dispersion of repolarization.
- M cell action potentials prolong significantly compared to other ventricular cells under certain conditions.
- Controversy exists regarding the functional significance of transmural heterogeneity of repolarization.
- High concentrations of quinidine can produce counterproductive effects on ion channels affecting TDR.
Structured PICO
P
Population
Ventricular myocardium M cells (review including dog models)
This review characterizes the M cell's role in ventricular electrophysiology and arrhythmias, suggesting that previous failures to detect its functional importance in vivo were likely due to methodological limitations.
Cite This Study
Antzelevitch et al. (1999) studied this question.