Evaluation of Novel Epothilone Analogues by means of a Common Pharmacophore and a QSAR Pseudoreceptor Model for Taxanes and Epothilones

Taxanes and epothilones: New insights into the binding mode of epothilone B with tubulin support a previous hypothesis based on a pseudoreceptor model, in which taxanes and epothilones binding in the β-tubulin binding pocket share several pharmacophoric elements. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.