What question did this study set out to answer?

The study aims to determine whether noncontrast T1 mapping provides a detailed characterization of myocardial tissue in hypertrophic and dilated cardiomyopathy.

October 17, 2012Circulation Cardiovascular ImagingOpen Access

Myocardial Tissue Characterization Using Magnetic Resonance Noncontrast T1 Mapping in Hypertrophic and Dilated Cardiomyopathy

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Why the study?

Does noncontrast T1 mapping characterize myocardial tissue beyond late gadolinium enhancement in patients with hypertrophic and dilated cardiomyopathy?

Key Points

The study aims to determine whether noncontrast T1 mapping provides a detailed characterization of myocardial tissue in hypertrophic and dilated cardiomyopathy.
Subjects underwent cardiovascular magnetic resonance imaging at 3T (28 HCM, 18 DCM, 12 normals).
T1 mapping measurements were correlated with late gadolinium enhancement findings and circumferential strain analysis.
Phosphorus magnetic resonance spectroscopy was performed for biochemical assessment of myocardial segments.
Mean T1 values were significantly higher in HCM (1209±28 ms) and DCM (1225±42 ms) compared to normals (1178±13 ms, P<0.05).
T1 values were higher in segments with LGE (HCM 1228±41 ms; DCM 1254±73 ms) compared to those without (P<0.01).
Significant negative correlation was observed between T1 values and phosphocreatine/adenosine triphosphate ratios (r=-0.59, P<0.0001).

Structured PICO

Does noncontrast T1 mapping characterize myocardial tissue beyond late gadolinium enhancement in patients with hypertrophic and dilated cardiomyopathy?

Population

58 subjects including 28 with hypertrophic cardiomyopathy (HCM), 18 with dilated cardiomyopathy (DCM), and 12 normal controls.

Intervention

Noncontrast T1 mapping using Cardiovascular Magnetic Resonance imaging at 3T.

Comparator

Late gadolinium enhancement (LGE) imaging (0.1 mmol/kg) and normal controls.

Outcome

Mean T1 relaxation time and its correlation with LGE, disease severity, circumferential strain, and phosphocreatine/adenosine triphosphate ratios.surrogate

Noncontrast T1 mapping detects underlying disease processes and diffuse fibrosis beyond focal fibrosis assessed by LGE in patients with HCM and DCM.

Discussion

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Implication

Noncontrast T1 mapping may detect diffuse changes beyond LGE in HCM/DCM; hypothesis-generating and should not yet change practice.

Cite This Study

Dass et al. (2012) studied this question.

synapsesocial.com/papers/6a088bf07de338f10b10c885 https://doi.org/10.1161/circimaging.112.976738

Topics

Cardiac MRI Hypertrophic cardiomyopathy

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Myocardial Tissue Characterization Using Magnetic Resonance Noncontrast T1 Mapping in Hypertrophic and Dilated Cardiomyopathy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Myocardial Tissue Characterization Using Magnetic Resonance Noncontrast T1 Mapping in Hypertrophic and Dilated Cardiomyopathy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider