Key result
Interleukin-18 stimulates fibronectin expression in adult human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation, and fibronectin conversely stimulates IL-18 expression.
Population
Adult human cardiac fibroblasts (HCF) in vitro
Comparison
Interleukin-18 (IL-18) stimulation vs Unstimulated control and/or specific pathway…
Design
Preclinical
Authors
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Identifies a novel profibrotic feedback loop in myocardial remodeling; leaves open whether targeting this.
IL-18 and fibronectin stimulate each other's expression in human cardiac fibroblasts via PI3K-Akt-dependent NF-κB activation, suggesting a mechanistic role in myocardial hypertrophy and fibrotic remodeling.
Reddy et al. (2007) studied Myocardial hypertrophy and failure. Interleukin-18 was evaluated on Fibronectin expression. Interleukin-18 stimulates fibronectin expression in adult human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation, and fibronectin conversely stimulates IL-18 expression.
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