Key result
Cardiac fibroblasts originate from multiple sources to drive heart development, homeostasis, and disease.
This review summarizes current knowledge on the developmental origins, markers, and lineage tracing of cardiac fibroblasts, highlighting their complex roles beyond mechanical support.
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Highlights fibroblast heterogeneity for targeted research; leaves open clinical translation in fibrosis.
Doppler et al. (2017) conducted a review in Cardiac fibroblasts. Cardiac fibroblasts originate from multiple sources including the epicardium, endocardium, and neural crest, and play important roles in development, homeostasis, and disease.
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