Key result
In a canine model of myocardial infarction, myofibroblasts in healing reperfused myocardium showed significant proliferative activity (PCNA index 13.7% at 5 days vs 4.8% at 28 days, P<0.05).
Absolute Event Rate: 13.7% vs 4.8%
p-value: p=<0.05
In a canine model of ischemia/reperfusion, myofibroblasts in healing infarcts express the embryonic form of smooth muscle myosin heavy chain (SMemb), indicating dedifferentiation during scar formation.
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No immediate implications for post-MI care; leaves open the role of early myofibroblast proliferation in human scar formation.
Nikolaos G. Frangogiannis (2000) studied Myocardial infarction (n=5). Coronary occlusion and reperfusion vs. Maturation phase (28 days) was evaluated on Proliferating cells (PCNA index) (p=<0.05). In a canine model of myocardial infarction, myofibroblasts in healing reperfused myocardium showed significant proliferative activity (PCNA index 13.7% at 5 days vs 4.8% at 28 days, P<0.05).
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