Key result
Adoptive transfer of myelin basic protein-activated lymph node cells induced EAE in 100% of recipient mice, a process dependent on Lyt 1+ 2- T lymphocytes.
Population
SJL/J mice
Comparison
Adoptive transfer of lymph node cells primed in… vs Treatment of activated lymph node cells with…
Design
Preclinical
Authors
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No immediate clinical implications for MS; leaves open translation of T-cell dependence from murine EAE models.
Lyt 1+ 2- T lymphocytes are required for the adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice.
Pettinelli et al. (1981) studied Experimental allergic encephalomyelitis (EAE). Adoptive transfer of lymph node cells activated in vitro by myelin basic protein vs. Treatment with anti-Thy 1, anti-Lyt 1, or anti-Lyt 2 antibodies before transfer was evaluated on Induction of EAE. Adoptive transfer of myelin basic protein-activated lymph node cells induced EAE in 100% of recipient mice, a process dependent on Lyt 1+ 2- T lymphocytes.