What question did this study set out to answer?

To assess whether clinical presentation, symptom profile, and disease severity differ across influenza types and subtypes in pediatric patients.

October 10, 2024Journal of the Pediatric Infectious Diseases SocietyOpen Access

Pediatric Clinical Influenza Disease by Type and Subtype 2015–2020: A Multicenter, Prospective Study

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To assess whether clinical presentation, symptom profile, and disease severity differ across influenza types and subtypes in pediatric patients.
Enrolled children aged 0–17 years with molecularly confirmed influenza across 8 New Vaccine Surveillance Network sites between 2015 and 2020.
Gathered clinical and demographic data through parental interviews and chart reviews, modeling hospital admission, supplemental oxygen need, and length of stay via multivariable logistic regression and Cox proportional hazard models adjusting for age, sex, subtype, and asthma history.
Odds of hospital admission were significantly higher among children with influenza A(H1N1)pdm09 (adjusted odds ratio [AOR]: 1.39, 95% CI: 1.14–1.69) and children with asthma (AOR: 2.14, 95% CI: 1.72–2.67).
Admitted children with influenza A(H1N1)pdm09 had significantly higher supplemental oxygen requirements than those with influenza A(H3N2) (AOR: 0.60, 95% CI: 0.44–0.82) or influenza B (AOR: 0.56, 95% CI: 0.41–0.76).
Retractions and cyanosis were observed more frequently in A(H1N1)pdm09 infections, whereas headaches and sore throat were more commonly reported with influenza B.

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Implication

Prospective multicenter study reveals greater disease severity with influenza A(H1N1)pdm09 in pediatric patients, indicating subtype-specific risks for respiratory complications.

Cite This Study

Grioni et al. (2024) studied this question.

synapsesocial.com/papers/6a0894bf113ba5b476de4c57 https://doi.org/10.1093/jpids/piae108

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Implication

Prospective multicenter study reveals greater disease severity with influenza A(H1N1)pdm09 in pediatric patients, indicating subtype-specific risks for respiratory complications.

Pediatric Clinical Influenza Disease by Type and Subtype 2015–2020: A Multicenter, Prospective Study

Key Points

Discussion

Implication

Cite This Study

Pediatric Clinical Influenza Disease by Type and Subtype 2015–2020: A Multicenter, Prospective Study

Key Points

Discussion

Implication

Cite This Study

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