Why the study?
Does T1-mapping-derived extracellular volume fraction (Ve) after bolus gadolinium administration accurately detect interstitial myocardial fibrosis in patients with pressure-overload left ventricular hypertrophy?
Cross-Sectional (n=63)
Does T1-mapping-derived extracellular volume fraction (Ve) after bolus gadolinium administration accurately detect interstitial myocardial fibrosis in patients with pressure-overload left ventricular hypertrophy?
Multi-slice T1-mapping Ve measurement after bolus gadolinium administration is clinically practical and correlates well with histology and indices of reduced myocardial performance for detecting interstitial myocardial fibrosis in pressure-overload hypertrophy.
Elevated Ve may signal interstitial fibrosis in pressure-overload hypertrophy; leaves open bolus T1-mapping accuracy pending validation.
International audience
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Jabbour et al. (2012) conducted a cross-sectional in Pressure-overload left ventricular hypertrophy (Aortic stenosis and systemic hypertension) (n=63). Multi-slice T1-mapping-derived extracellular volume fraction (Ve) measurement vs. Healthy controls was evaluated on Extracellular volume fraction (Ve) (p=<0.01).
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