Key result
Cortisol, endothelial dysfunction, pro-inflammatory cytokines, and allostatic load are linked to CVD outcomes during psychosocial stress.
Why the study?
The association between psychosocial stressors and cardiovascular diseases had been suggested, prompting an evaluation of the pertinence of new biomarkers in CVD occurrence or prognosis in a psychosocial context.
Are candidate biomarkers (cortisol, endothelial dysfunction, pro-inflammatory cytokines, allostatic load) associated with the incidence or prognosis of cardiovascular diseases in the context of psychosocial stress?
Are candidate biomarkers (cortisol, endothelial dysfunction, pro-inflammatory cytokines, allostatic load) associated with the incidence or prognosis of cardiovascular diseases in the context of psychosocial stress?
Candidate biomarkers including cortisol, inflammatory cytokines, and allostatic load index may help evaluate the cardiovascular risk associated with psychosocial stressors.
May aid psychosocial stress-related CVD risk stratification; leaves open prospective validation before clinical use.
Introduction: The association between psychosocial stressors and cardiovascular diseases had been suggested. Aims: This review was performed to assess, from literature data, the pertinence of using new biomarkers in the occurrence or prognosis of cardiovascular diseases in a psychosocial context. Methods: We choose to consider wide-ranging descriptions of psychological stressors (occupational stress, financial strain, marital stress, social isolation, etc.) that may induce or influence the cardiovascular diseases’ outcome. We addressed literature data confirming the link between candidate biomarkers, such as cortisol, endothelial dysfunction, pro-inflammatory cytokines, allostatic load, and cardiovascular diseases. Results and Conclusion: Herein we showed a link between cortisol, endothelial dysfunction, pro-inflammatory cytokines, and the incidence or prognosis of cardiovascular diseases in a psychosocial context of stress. Allostatic load index was also identified as a pertinent tool in the assessment of the cumulative psychosocial stressors’ burden exerted on the body.
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Ayari et al. (2023) conducted a review in Cardiovascular diseases. Candidate biomarkers (cortisol, endothelial dysfunction, pro-inflammatory cytokines, allostatic load) was evaluated on Incidence or prognosis of cardiovascular diseases. Cortisol, endothelial dysfunction, pro-inflammatory cytokines, and allostatic load index are linked to the incidence or prognosis of cardiovascular diseases in the context of psychosocial stress.
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