Key result
Elevated PILRA expression in AF rats correlates with multiple types of immune cell infiltration.
Why the study?
Inflammation plays an important role in AF, but the significance of immune cell infiltration and the potential hub genes regulating it needed investigation.
Population
AF datasets from the GEO database and an AF rat model
Comparison
Rats with AF vs rats without AF
Design
Bioinformatics analysis and preclinical experimental validation study
Authors
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PILRA may be a candidate AF target; animal data leave open its clinical relevance and therapeutic potential.
PILRA is identified as a potential hub gene associated with immune cell infiltration in atrial fibrillation, suggesting it may be a novel therapeutic target.
Shi et al. (2023) studied Atrial fibrillation. PILRA expression analysis vs. Rats without atrial fibrillation was evaluated on PILRA expression level and correlation with immune cell infiltration. PILRA expression was significantly elevated in rats with atrial fibrillation and positively correlated with multiple types of immune cell infiltration.
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