Key result
ALIVE pilot evaluates LA fibrosis before and after mitral valve repair in primary MR.
Why the study?
Literature on the presence and extent of LA fibrosis in MR patients is scarce, and its clinical implications remain unknown.
Does mitral valve repair surgery affect left atrial fibrosis and reversed atrial remodeling in patients with mitral regurgitation without atrial fibrillation?
Does mitral valve repair surgery affect left atrial fibrosis and reversed atrial remodeling in patients with mitral regurgitation without atrial fibrillation?
The ALIVE trial will provide novel insights into the pathophysiological mechanism of fibrotic and volumetric atrial remodeling in MR patients undergoing MVR surgery.
No takes yet. Share an insight, caveat, or question.
Pilot data on LA fibrosis pre/post-MVR may inform mechanisms; leaves open reversal of atrial remodeling in MR without AF.
Mathari et al. (2023) studied Primary mitral regurgitation (n=20). Mitral valve repair surgery vs. Matched control group without MR and no AF was evaluated on Extent and geometric distribution of LA fibrosis. The ALIVE trial is a prospective pilot study designed to evaluate the presence, extent, and geometric distribution of left atrial fibrosis in 20 patients with primary mitral regurgitation before and after mitral valve repair surgery.
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