Astragaloside IV demonstrates cardioprotective effects against post-MI remodeling and fibrosis in preclinical models by inhibiting macrophage pyroptosis.
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Supports AS-IV for post-MI remodeling in animals; leaves open clinical translation.
, AS-IV was selected to stimulate bone marrow-derived macrophages (BMDMs). Our findings indicated that AS-IV protective effect of the heart might be related to the reduction of macrophage pyroptosis. These results demonstrate that AS-IV alleviated MI-induced myocardial fibrosis and cardiac remodeling by suppressing ROS/Caspase-1/GSDMD signaling pathway, AS-IV should be further studied in the future.
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Zhang et al. (2022) studied this question.
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