Key result
Elongation factor P maintains protein yield and homeostasis during rapid growth by relieving ribosome queuing.
EF-P is critical for maintaining proteome homeostasis and protein yield specifically under rapid growth conditions by alleviating ribosome pausing.
Should not change clinical practice; hypothesis-generating for EF-P targeting in proliferative states.
Significance Adaptation to rapidly changing environments is essential for cellular fitness and is a critical component in pathogenesis. Translational control has important roles for fitness in a range of environments and requires multiple factors for efficient responses. One such factor is the translation elongation factor (EF)-P, which alleviates ribosome pausing at polyproline motifs. Our findings show that EF-P-mediated relief of ribosome queuing is integral in environmentally driven changes to translation rates. We observe that ribosome pausing leads to changes in protein yield only under rapid growth conditions, demonstrating that effects resulting from ribosome queuing correlate directly with translational demand. These results provide physiological context to previous studies establishing EF-P as a critical factor in cell growth and virulence.
No takes yet. Share an insight, caveat, or question.
Tollerson et al. (2018) studied Cellular fitness and pathogenesis. Elongation factor P (EF-P) was evaluated on Protein yield and translation rates. Elongation factor P-mediated relief of ribosome queuing is integral to maintaining protein yield and proteome homeostasis specifically under rapid growth conditions.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: