Why the study?
The study aimed to assess how sacubitril/valsartan altered the early recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation.
Does sacubitril/valsartan reduce the early recurrence of atrial fibrillation in patients with paroxysmal atrial fibrillation and cardiac insufficiency undergoing radiofrequency ablation?
Population
100 patients with paroxysmal AF and cardiac insufficiency
Comparison
Sacubitril/valsartan vs perindopril tert-butylamine after radiofrequency catheter ablation
Design
Randomized controlled trial
Follow-up
3 mo
Authors
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Supports sacubitril/valsartan over perindopril to reduce early AF recurrence after ablation; extends ARNI data to post-procedural arrhythmia prevention.
Does sacubitril/valsartan reduce the early recurrence of atrial fibrillation in patients with paroxysmal atrial fibrillation and cardiac insufficiency undergoing radiofrequency ablation?
Sacubitril/valsartan significantly reduces the early recurrence of paroxysmal atrial fibrillation and improves cardiac structure/function after radiofrequency ablation in patients with cardiac insufficiency compared to perindopril.
Li et al. (2024) studied this question.