Key points are not available for this paper at this time.
Abstract In this study, biocompatible Fe(III) species‐WS 2 ‐polyvinylpyrrolidone (Fe(III) @ WS 2 ‐PVP) nanocapsules with enhanced biodegradability and doxorubicin (DOX) loading capacity are one‐pot synthesized. In this nanocapsule, there exists a redox reaction between Fe(III) species and WS 2 to form Fe 2+ and WO 4 2− . The formed Fe 2+ could be oxidized to Fe 3+ , which reacts with Fe(III) @ WS 2 ‐PVP again to continuously produce Fe 2+ and WO 4 2− . Such a repeated endogenous redox reaction leads to an enhanced biodegradation and DOX release of DOX @ Fe(III) @ WS 2 ‐PVP. More strikingly, the Fe 2+ generation and DOX release are further accelerated by the overexpressed H 2 O 2 and the mild acidic tumor microenvironment (TME), since H 2 O 2 and H + can accelerate the oxidation of Fe 2+ . The continuously generated Fe 2+ catalyzes a fast Fenton reaction with the innate H 2 O 2 in tumor cells and produces abundant highly toxic hydroxyl radicals for nanocatalytic tumor therapy. Together with the high photothermal transforming capability, the DOX @ Fe(III) @WS 2 ‐PVP nanocapsules successfully achieve the endogenous redox reaction and exogenous TME‐augmented tumor photothermal therapy, chemo and nanocatalytic therapy outcome. The concept of material design can be innovatively extended to the synthesis of biodegradable Fe(III) @ MoS 2 ‐PVP nanocomposite, thus paving a promising novel way for the rational design of intelligent theranostic agents for highly efficient treatment of cancer.
Wu et al. (Wed,) studied this question.