Key result
TNF-α and IL-1β gene polymorphisms linked to up to ~227% greater Type 2 diabetes risk.
Why the study?
Cytokines regulate inflammation and tissue repair, but the feasible relationship between TNF-alpha, IL-1beta, and IL-6 cytokine gene polymorphisms and Type 2 diabetes development and progression in Turkish subjects needed investigation.
Are TNF-α, IL-1β, and IL-6 cytokine gene polymorphisms associated with the development and complications of Type 2 diabetes in a Turkish population?
Case-Control (n=300)
No
Are TNF-α, IL-1β, and IL-6 cytokine gene polymorphisms associated with the development and complications of Type 2 diabetes in a Turkish population?
TNF-α (-308) and IL-1β (+ 3953) gene polymorphisms are significantly associated with the development and progression of Type 2 diabetes in the Turkish population.
May inform T2D risk assessment in Turkish patients; leaves open replication in diverse cohorts before clinical use.
Type 2 Diabetes is a metabolic defect with an extreme enhancement of blood glucose level developed by the united effects of environmental and genetic factors and also related with micro and macrovascular complications. Researches pointed out the connections between disease and the inflammation. Cytokines have important role in administration of the homeostatic processes including tissue repair and inflammation. Single nucleotide polymorphisms (SNP) of some cytokine genes have an impact on the expression levels of these genes enhancing the risk of the disease development. Ultimate studies demonstrated several liaisons between cytokine gene polymorphisms and the development and progression of type 2 diabetes. In this research, we intended to elicit the feasible relationship between TNF-α, IL-1β and IL-6 cytokine gene polymorphisms and development of Type 2 diabetes and the progression of the complications in Turkish subjects. The DNA specimens of all individuals are isolated then PCR-RFLP (Polymerase chain reaction-Restriction fragment length polymorphism) method was performed as genotyping analysis. Our data indicate that TNF-α (-308) and IL-1β (+ 3953) gene polymorphisms have significant effects on both development of the disease (3.27 and 2.15 respectively) and its complications (4.15 and 2.81 respectively). In regards to our results we suggest that TNF-α and IL-1β gene polymorphisms have an important role in developing and progressing of Type II diabetes in Turkish population.
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Ateş et al. (2024) conducted a case-control in Type 2 Diabetes (n=300). TNF-α (-308) gene polymorphism vs. Healthy controls (wild-type genotype) was evaluated on Development of Type 2 Diabetes (OR 3.27, 95% CI 1.51-5.89, p=<0.001). TNF-α (-308) and IL-1β (+3953) gene polymorphisms significantly increased the risk of developing Type 2 diabetes by 3.27-fold and 2.15-fold, respectively, compared to healthy controls.
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