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March 1, 2003DiabetesOpen Access

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes

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Key result

A combined elevation of IL-1beta and IL-6 independently increased the risk of developing type 2 diabetes compared with a low-level reference group (OR 3.3; 95% CI 1.7-6.8).

Why the study?

Do elevated levels of inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) predict the development of type 2 diabetes in individuals free of the disease at baseline?

Population

192 incident cases of type 2 diabetes and 384 matched non-disease-developing control subjects, drawn from…

Comparison

Elevated levels of inflammatory cytokines vs Low or undetectable levels of inflammatory…

Design

Case-control

Follow-up

2.3 years

Authors

JSJoachim SprangerUniversity of Wisconsin–MadisonAKAnja KrokeFulda University of Applied SciencesMMMatthias MöhligUniversity of the Witwatersrand

Discussion

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Implication

May flag higher T2D risk; hypothesis-generating for inflammation-targeted prevention.

Study Design

Type

Case-Control (n=576)

Structured PICO

Do elevated levels of inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) predict the development of type 2 diabetes in individuals free of the disease at baseline?

P
Population
192 incident cases of type 2 diabetes and 384 matched non-disease-developing control subjects, drawn from the EPIC-Potsdam study of 27,548 individuals free of type 2 diabetes at baseline.
I
Intervention
Elevated levels of inflammatory cytokines (IL-1beta, IL-6, TNF-alpha)
C
Comparator
Low or undetectable levels of inflammatory cytokines
O
Outcome
Development of incident type 2 diabeteshard clinical

Main Result

Effect estimate: OR 3.3 (95% CI 1.7-6.8)

A combined elevation of IL-1beta and IL-6 independently increases the risk of developing type 2 diabetes, supporting the role of subclinical inflammation in its pathogenesis.

Cite This Study

Spranger et al. (2003) conducted a case-control in Type 2 diabetes (n=576). Elevated IL-6 and detectable IL-1beta vs. Low-level reference group was evaluated on Incident type 2 diabetes (OR 3.3, 95% CI 1.7-6.8). A combined elevation of IL-1beta and IL-6 independently increased the risk of developing type 2 diabetes compared with a low-level reference group (OR 3.3; 95% CI 1.7-6.8).

synapsesocial.com/papers/6a0ca356e28175e95a236f42https://doi.org/10.2337/diabetes.52.3.812
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Also Consider

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